Hypoglycemia has not been seen with ingestion of up to 85 grams of metformin hydrochloride, although lactic acidosis has occurred in such circumstance. Metformin is dialyzable with a clearance of up to 170 ml/min under good hemodynamic conditions. Therefore, hemodialysis may be useful for removal accumulated metformin from patients in whom metformin overdosage is suspected.
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